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**Why is it so important to understand this?** Because the lack of these receptors changes the treatment approach significantly. Traditional hormone therapies, which work by targeting ER and PR, and HER2-targeted therapies simply won't work for TNBC. This is why for many years, chemotherapy was the primary treatment option. While chemotherapy can be effective, it also comes with significant side effects, and the cancer can sometimes develop resistance over time. Historically, this has made TNBC a tough nut to crack, which is why current research breakthroughs are such a big deal.
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Noel Gallagher has had a profound impact on music, both as a songwriter and as a cultural figure. Here are a few ways he has influenced the music world:
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